Sco2 deficient mice develop increased adiposity and insulin resistance
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چکیده
منابع مشابه
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by thiazolidinediones (TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal muscle. It remains debatable whether the effect of TZDs on muscle is direct or indirect via adipose tissue. We therefore generated mice with muscle-specific PPARgamma knockout (MuPPARgammaKO) using Cre/l...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2017
ISSN: 0303-7207
DOI: 10.1016/j.mce.2017.03.019